True or False: First-generation rodenticides must be fed upon more than once for rodents to receive a lethal dose.

The statement that first-generation rodenticides must be fed upon more than once for rodents to receive a lethal dose is true. First-generation rodenticides, which are anticoagulants, typically require multiple feedings over several days to accumulate a lethal dose in the rodent's system. These compounds work by interfering with the rodent's ability to clot blood, leading to death from internal bleeding.

In contrast, second-generation rodenticides are designed to be more potent, often resulting in a lethal dose after just one feeding, which increases their effectiveness in controlling infestations in a shorter time frame. The need for repeated exposure with first-generation rodenticides emphasizes their safety, as it reduces the risk of accidental toxicity to non-target animals and creates a slower, more controlled method of rodent population management. This characteristic of first-generation rodenticides makes them a commonly recommended option for use in various settings, especially those where non-target wildlife and pets may be a concern.